Notify sufferers that a home teaspoon isn't an accurate measuring machine and this kind of use could lead on to overdosage and major adverse reactions [see OVERDOSAGE (10)]. For prescriptions the place a measuring unit is not delivered, a pharmacist can provide an proper calibrated measuring gadget and can provide instructions for measuring the right dose.

Postmarketing scenarios of respiratory melancholy, such as fatalities, are already documented with usage of promethazine in pediatric sufferers. Concomitant administration with other respiratory depressants may perhaps boost the danger of respiratory depression.

The effects of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are elaborate, requiring very careful consideration of the effects to the father or mother drug, codeine, along with the Lively metabolite, morphine.

The administration of codeine overdose would not stop within the unexpected emergency Division or with the prescribing clinician. Once the client is stabilized, clinicians really should try to confirm how and why the affected person overdosed. Consultation by using a mental health counselor is recommended to ascertain no matter whether it was an intentional act of self-damage because of the patient.

Not less than one Loss of life was claimed in a nursing infant who was exposed to substantial amounts of morphine in breast milk because the mom was an ultra-speedy metabolizer of codeine.

Prior to getting this medication, notify your health practitioner or pharmacist In case you are allergic to promethazine or to dextromethorphan; or to some other phenothiazines (including prochlorperazine); or When you've got any other allergy symptoms.

The Drug Enforcement Administration classifies codeine and hydrocodone within their pure forms as Program II medicine. This suggests they've got a high opportunity for misuse and can cause critical Bodily or psychological dependence.

Evaluate Just about every affected person's chance ahead of prescribing Promethazine with Codeine Oral Resolution, prescribe Promethazine with Codeine Oral Resolution for the shortest duration that is in line with personal affected individual treatment method plans, keep an eye on all people regularly for the event of addition or abuse, and refill only soon after reevaluation of the need for ongoing treatment. [see Warnings and Safeguards (5.one)]

Codeine could improve the neuromuscular blocking action of skeletal muscle mass relaxants and create an increased diploma of respiratory depression.

Dosages vary, but several sorts of hydrocodone are gradual-releasing to forestall addiction, and Medical professionals generally prescribe either drug together with other medications, based on the ailment. These medications also function as cough suppressants.

Codeine causes a reduction in motility affiliated with a rise in easy muscle mass tone from the antrum of your tummy and duodenum. Digestion of food inside the little intestine is delayed and propulsive contractions are diminished.

Circumstances OF USE: The data in this database is meant to complement, not substitute for, the knowledge and judgment of Health care gurus. The information is just not meant to deal with all doable uses, directions, safety measures, drug interactions or adverse consequences, nor must or not it's construed to point that utilization of a specific drug is Risk-free, proper or efficient for you or anybody else.

Most MAO inhibitors must also not be taken for two weeks just before cure using this type of medication. Request your physician when to start or prevent taking Promethazine codeine syrup this medication.

Choose this medication precisely as prescribed to decrease the potential risk of dependancy. Talk to your physician or pharmacist for more specifics.